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KMID : 1094020130300040241
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Journal of Veterinary Clinics
2013 Volume.30 No. 4 p.241 ~ p.246
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Effects of Chitosan on Wound Healing in Monkeys
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Byun Hong-Seob
Lee Soo-Jin
Lee Jae-Il
Kim Moo-Kang
Shin Nam-Shik
Kim Myung-Cheol
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Abstract
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The objective of this study was to investigate the effects of implanted chitosan applied to surgically created wound in Japanese Macaque monkeys. 4 healthy Japanese Macaque monkeys were used. A 4 cm straight skin incision was made and undermined skin (4 × 4 cm) over on the 2 monkeys both sides of the dorsal midline, and a 4 cm circular skin incision was made on 2 monkeys both sides of the dorsal midline. One wound (left side) was implanted 1 mg (straight incision) and daily 0.2 mg (circular incision) of cotton type chitosan and the other wounds were treated with normal saline (3 ml) in monkeys. Each straight wound was closed with two interrupted sutures of 2-0 sutures. The monkey"s circular skin incision is opened. At 14 days after initial wounding, each wound was taken for histological observations in monkeys. The inflammatory cells in the chitosan group are observed less than the control group, the collagen and the fibrin in the chitosan are observed more than the control group in monkeys. So the wound healing is moderately enhanced for chitosan treatment. The fibroblasts and the capillaries increased for chitosan treatment. The treatment of chitosan in wound is to promote healing.
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KEYWORD
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skin, wound healing, monkey, chitosan, histological observation
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